Table 8.
Cox’s Proportional Hazards Regression Model Analysis of Factors Affecting OS
| Parameters | Univariate Cox’s Regression | Multivariate Cox’s Regression | ||||||
|---|---|---|---|---|---|---|---|---|
| p Value | HR | 95% CI | p Value | HR | 95% CI | |||
| Lower | Higher | Lower | Higher | |||||
| Age ≥65 years | 0.191 | 0.437 | 0.126 | 1.512 | – | – | – | – |
| Male | 0.550 | 1.459 | 0.422 | 5.042 | – | – | – | – |
| History of HB | 0.982 | 1.012 | 0.380 | 2.696 | – | – | – | – |
| History of HC | 0.727 | 0.049 | 0.000 | 1156342 | – | – | – | – |
| History of drink | 0.475 | 1.400 | 0.556 | 3.528 | – | – | – | – |
| History of cirrhosis | 0.516 | 0.730 | 0.283 | 1.886 | – | – | – | – |
| Primary HCC | 0.772 | 0.858 | 0.306 | 2.409 | – | – | – | – |
| Primary ICC | 0.928 | 1.070 | 0.246 | 4.658 | – | – | – | – |
| Secondary liver cancer | 0.781 | 1.192 | 0.345 | 4.119 | – | – | – | – |
| Multifocal disease | 0.391 | 1.628 | 0.535 | 4.951 | – | – | – | – |
| Tumor location: left liver | 0.248 | 0.038 | 0.000 | 9.696 | – | – | – | – |
| Tumor location: right liver | 0.702 | 0.834 | 0.329 | 2.115 | – | – | – | – |
| Tumor location: bilobar | 0.083 | 2.280 | 0.898 | 5.788 | 0.683 | 1.301 | 0.367 | 4.609 |
| Largest nodule size ≥5 cm | 0.017 | 4.538 | 1.311 | 15.703 | 0.048 | 6.003 | 1.015 | 35.500 |
| Portal vein invasion | 0.016 | 3.146 | 1.241 | 7.975 | 0.684 | 1.304 | 0.363 | 4.686 |
| Hepatic vein invasion | 0.693 | 1.284 | 0.371 | 4.437 | – | – | – | – |
| Higher ECOG performance status | 0.088 | 1.551 | 0.936 | 2.570 | 0.741 | 1.125 | 0.558 | 2.269 |
| Higher Child–Pugh Stage | 0.001 | 1.688 | 1.226 | 2.324 | 0.318 | 1.603 | 0.635 | 4.047 |
| Higher BCLC stage | 0.058 | 2.081 | 0.975 | 4.442 | 0.644 | 1.256 | 0.479 | 3.292 |
| Two or more cycles of DEB-TACE treatment | 0.299 | 0.457 | 0.104 | 2.002 | – | – | – | – |
| Previous cTACE treatment | 0.668 | 0.807 | 0.303 | 2.151 | – | – | – | – |
| Previous Surgery | 0.248 | 0.481 | 0.139 | 1.665 | – | – | – | – |
| Previous systematic chemotherapy | 0.541 | 1.472 | 0.426 | 5.089 | – | – | – | – |
| Previous radiofrequency ablation | 0.775 | 1.198 | 0.347 | 4.140 | – | – | – | – |
| Previous targeted therapy | 0.601 | 0.047 | 0.000 | 4443.2 | – | – | – | – |
| Higher DEBs size | 0.448 | 2.190 | 0.289 | 16.587 | – | – | – | – |
| Higher drug dosage | 0.744 | 0.783 | 0.180 | 3.406 | – | – | – | – |
| Combination of ordinary embolization agent | 0.331 | 1.586 | 0.626 | 4.021 | – | – | – | – |
| WBC abnormal | 0.079 | 2.300 | 0.907 | 5.833 | 0.680 | 1.311 | 0.361 | 4.758 |
| RBC abnormal | 0.021 | 3.232 | 1.194 | 8.748 | 0.559 | 1.423 | 0.435 | 4.651 |
| ANC abnormal | 0.076 | 2.367 | 0.913 | 6.135 | 0.784 | 0.809 | 0.178 | 3.668 |
| Hb abnormal | 0.358 | 1.563 | 0.603 | 4.055 | – | – | – | – |
| PLT abnormal | 0.906 | 1.059 | 0.410 | 2.738 | – | – | – | – |
| ALB abnormal | 0.001 | 9.077 | 2.620 | 31.442 | 0.044 | 4.667 | 1.046 | 20.829 |
| TP abnormal | 0.122 | 2.119 | 0.819 | 5.481 | – | – | – | – |
| TBIL abnormal | 0.005 | 3.783 | 1.491 | 9.597 | 0.048 | 3.891 | 1.010 | 14.985 |
| TBA abnormal | 0.483 | 1.395 | 0.550 | 3.536 | – | – | – | – |
| ALT abnormal | 0.508 | 1.417 | 0.505 | 3.979 | – | – | – | – |
| AST abnormal | 0.099 | 2.220 | 0.860 | 5.733 | 0.743 | 0.786 | 0.187 | 3.313 |
| ALP abnormal | 0.014 | 3.424 | 1.284 | 9.128 | 0.545 | 0.998 | 0.992 | 1.004 |
| BCr abnormal | 0.004 | 4.174 | 1.573 | 11.076 | 0.086 | 3.225 | 0.848 | 12.257 |
| BUN abnormal | 0.056 | 2.701 | 0.976 | 7.474 | 0.470 | 1.604 | 0.444 | 5.790 |
| AFP abnormal | 0.591 | 1.303 | 0.496 | 3.425 | – | – | – | – |
| CEA abnormal | 0.601 | 1.326 | 0.461 | 3.817 | – | – | – | – |
| CA199 abnormal | 0.116 | 2.196 | 0.824 | 5.855 | – | – | – | – |
Data are presented as p value, HR (hazards ratio), and 95% CI. Factors affecting overall survival (OS) were determined by univariate Cox’s proportional hazards regression model analysis. All factors with p value no more than 0.1 were further detected by multivariate Cox’s proportional hazards regression analysis. A value of p < 0.05 was considered significant (bold). Child–Pugh stage was scored as 0—A, 1—B, 2—C; BCLC stage was scored as 0—stage 0, 1—stage A, 2—stage B, 3—stage C, 4—stage D. The Cox’s proportional hazards analysis was performed based on these definitions.