FIG 2.

Supplementation of the diet with SP reduces the innate inflammatory response in the cornea. C57BL/6 mice that were orally fed SP or used as controls were infected with HSV-1, and FACS analysis was performed after 15 days p.i. (A, B) Total-leukocyte response in corneal tissue, shown as frequencies (A) and numbers (B) of leukocytes. (C, D) Representative FACS plots showing frequencies of total CD45⁺ cells infiltrating corneal tissue at 15 days p.i. (E, F) Neutrophil accumulation in the cornea, shown as frequencies (E) and numbers (F) of neutrophils. (G, H) FACS plots revealing frequencies of neutrophil (CD45⁺ CD11b⁺ Ly6G⁺) infiltration in corneas. (I) Total numbers of macrophages present in corneas. (J, K) FACS plots showing frequencies of macrophages (CD45⁺ CD11b⁺ F4/80⁺) infiltrating corneas. Data represent mean results ± SEM. All data were analyzed by an unpaired Student t test, and significance levels were determined (*, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P ≤ 0.0001).