FIG 8.

Effects of dietary SP supplementation on cytokine and chemokine expression levels in the corneas of HSV-1-infected animals. Orally SP-fed and control C57BL/6 mice infected with HSV-1 were sacrificed on day 15 p.i., and corneas were collected for measurement of the mRNA expression levels of various cytokines (IL-1β, IL-12, IL-6, TNF-α, MMP-9, IL-10, and TGF-β) and chemokines (CXCL1/KC and CCL3) in pooled corneal samples by quantitative RT-PCR. Samples consisted of four corneas per group from control and SP-fed animals. Data represent mean results ± SEM. All data were analyzed by an unpaired Student t test, and significance levels were determined (*, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P ≤ 0.0001).