FIG 4.

Seroconversion of NHPs given COBRA SVP vaccinations. (a) Schematic of COBRA SVP vaccinations in naive and preimmune NHPs. (b to e) Antibody binding to E of DENV1 to -4. Vaccine groups are listed on the x axis. Total IgG binding of sera (1:100 dilution) from individual NHPs was measured by the optical density (OD) values. Absorbance was measured at 405 nm. Unfilled bars, day 0; filled bars, day 70. Paired t tests were done to compare day 0 and day 70 values. Preimmune groups were analyzed by two-tailed paired t tests, and naive groups were analyzed by one-tailed paired t tests, with the confidence level at 95%. P values of <0.05 were considered statistically significant. *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P ≤ 0.0001.