TABLE 1.

IgG subclasses elicited by WT and COBRA SVP vaccines^a

^aEach panel shows IgG subclass binding of homologous monovalent WT SVPs, WT tetravalent SVPs, COBRA E SVPs, and COBRA tetravalent SVPs to commercial E antigen representing DENV1 (a), DENV2 (b), DENV3 (c), and DENV4 (d). Asterisks represent statistical significance, measured against the PBS control group, using an unpaired t test with Welch’s correction, with the color intensity increasing with significance. ns, nonsignificant (P > 0.05); *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P ≤ 0.0001.