Table 1.

Response Profiles of Deorphaned Coelacanth and Zebrafish T2Rs with Bitter Compounds

Substance	Source	Coelacanth		Zebrafish
		T2R01	T2R02	T2R1	T2R2	T2R3a	T2R4
Acetaminophen	S					•
Amarogentin	N, P, T					•
Andrographolide	N, P, T		•
Androsterone	N, Ap, TA		•
Benzoate, sodium salt	N, Pa, TA	•		•			•
Chenodesoxycholate, sodium salt	N, A, TA		•
Chloramphenicol	N, B, TA					•
Chloroquine	S	•		•		•
Colchicine	N, P, T					•
Coumarin	N, P, TA						•
Denatonium benzoate	S	•		•		•
Denatonium saccharide	S					•
Desoxycholate, sodium salt	N, A, TA		•
Dimethyl sulfoxide (DMSO)	Sn, TA						•
(-)-Epicatechin	N, P, T					•
Epigallocatechin gallate	N, P, T						•
Glycocholate, sodium salt	N, A, TA		•
Papaverine	N, P, T					•
1,10-Phenanthroline	S					•
Progesterone	N, Ap, TA		•
6-n-propyl-2-thiouracil (PROP)	S					•
Quassin	N, P, T						•
Quinine sulphate	N, P, T					•
Santonin	N, P, T					•
Strychnine	N, P, T					•
Taurocholic acid	N, A, TA		•
Taurolithocholic acid	N, A, TA		•		•		•
Umbelliferone	N, P, TA					•
Xanthotoxin	N, P, T					•

Note.—First group of symbols, natural compound (N), synthetic compound (S); second group of symbols, plant (P), animal (A), bacterial (B) metabolite; third group of symbols, terrestrial (T), aquatic (A) occurrence. Small letters indicate minor sources.