Table I.
Laboratory findings prior to enzyme treatment therapy.
| Parameter | Value | Normal reference range/limit |
|---|---|---|
| Hematology | ||
| White blood cells (x103/µl) | 6.2 | 4.0-12.0 |
| Hemoglobin (g/dl) | 10.4 | 11.5-14.5 |
| Hematocrit (%) | 32.9 | 33.0-45.0 |
| Platelets (x103/µl) | 3.5 | 15.0-40.0 |
| Leukocyte count | ||
| Neutrophils (%) | 49.0 | 38.0-68.0 |
| Lymphocytes (%) | 40.0 | 27.0-47.0 |
| Monocytes (%) | 9.0 | 3.0-7.0 |
| Blood chemistry | ||
| Total bilirubin (mg/dl) | 0.84 | 0.40-1.00 |
| Aspartate aminotransferase (U/l) | 45 | 20-60 |
| Alanine aminotransferase (U/l) | 13 | 5-45 |
| Alkaline phosphatase (U/l) | 253 | 410-1,150 |
| Gamma-glutamyl transpeptidase (U/l) | 14 | 5-32 |
| Total protein (g/dl) | 6.7 | 6.1-7.9 |
| Albumin (g/dl) | 4.39 | 3.40-5.10 |
| Blood urea nitrogen (mg/dl) | 11.0 | 5.0-18.0 |
| Creatinine (mg/dl) | 0.20 | 0.17-0.37 |
| Sodium (mEq/l) | 139 | 134-143 |
| Potassium (mEq/l) | 4.3 | 3.3-4.6 |
| Chloride (mEq/l) | 107 | 98-106 |
| Immunoglobulin G (mg/dl) | 631 | 345-1,236 |
| Coagulation | ||
| Prothrombin time activity (%) | 102.0 | 70.0-120.0 |
| Activated partial thromboplastin time (sec) | 39.1 | |
| Fibrinogen (mg/dl) | 417 | 130-350 |
| Acid phosphatase (U/l) | 134.2 | <14.4 |
| Angiotensin-converting-enzyme (U/µl) | 103.2 | 9.3-21.4 |
| Leukocyte β-glucosidase (nmol/h/mg) | 186.7 | 1,424.0-2,338 |