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. 2021 Jan 18;21(3):221. doi: 10.3892/etm.2021.9652

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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B355252 inhibits glutamate-induced change mitochondrial fusion markers. Representative western blots and quantitative analysis of the protein bands of the mitochondrial fusion proteins Opa1, Mfn1 and Mfn2. Glutamate exposure significantly increased the levels of the mitochondrial fusion markers Opa1, Mfn1 and Mfn2 without affecting the levels of Cox-IV after 18 h, and B355252 attenuated the glutamate-induced increase of these markers. Data are from three or more independent experiments conducted in triplicate. Values are presented as means ± SD and were analyzed by one-way ANOVA followed by Tukey's multiple comparison test. ^*P<0.05 and ^**P<0.01 vs. untreated control; ^#P<0.05 and ^##P<0.01 vs. Glu. Glu, 2 mM glutamate; Mfn1, mitofusin 1; Mfn2, mitofusin 2; Opa1, optic atrophy 1; Cox-IV, mitochondrial cytochrome c oxidase subunit IV.