Table I.
Studies investigating the effect of melatonin on lung injury.
| First author (year) | Studied model | Disease | Main findings | Refs. |
|---|---|---|---|---|
| Campos (2004) | Human | Asthma | Significantly improve sleep quality inhibits neutrophil movement and adhesion, decreases edema, neutrophil infiltration in experimental rats induced lung injury | (98) |
| Ozdinc (2016) | Rat | Acute lung injury | (75) | |
| Chiu (2012) | Rat | Lung ischemia-reperfusion injury | Diminish the pulmonary microvascular permeability and attenuate lipid peroxidation | (46) |
| Wang (2004) | Rat | Asthma | Inhibits the expression of NF-κβ and downregulates the inducible NO synthesis activity | (93) |
| He (2019) | Rat | Chronic obstructive pulmonary disease | Suppresses apoptosis and endoplasmic reticulum stress and increases the expression of silent information regulator 1 | (102) |
| Pedreira (2008), Gu (2015) | Rat | Ventilator-induced lung injury | Increasing the anti-inflammatory (IL-10) response and stabilizing cytoskeleton structure and the activation of target genes | (6,112) |