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. 2021 Jan 20;21(3):230. doi: 10.3892/etm.2021.9661

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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TP53INP1 reverses the inhibitory effect of miR-1323 on trophoblast viability in HG-treated HTR-8/SVneo and BeWo cells. (A and B) TP53INP1 expression was inhibited by HG treatment in the two cell lines. In the HG-treated two cell lines, the inhibited TP53INP1 expression by miR-1323 overexpression was increased by the pcDNA3.1-TP53INP1. (C and D) In the HG-treated two cell lines, the increase in TP53INP1 expression reversed the inhibitory effect of miR-1323 overexpression on trophoblast cell viability. ^*P<0.05 vs. normal; ^#P<0.05 vs. HG; and ^&P<0.05 vs. mimic. miR, microRNA; HG, high glucose.