Table 2.
Number of extra major adverse cardiac events (MACEs)
| Item | Primary analysis | Sensitivity analysis | |||||
|---|---|---|---|---|---|---|---|
| 1 year lag | Based on CMA | No lag | 6 month lag | 2 year lag | 5 year lag | ||
| Cut-off point: | |||||||
| Stable angina pectoris | Mar 2008 | Jan 2003 | Mar 2007 | Sep 2007 | Mar 2009 | Mar 2012 | |
| Acute coronary syndrome | Apr 2008 | Jan 2005 | Apr 2007 | Oct 2007 | Apr 2009 | Apr 2012 | |
| No of redundant trials: | |||||||
| All | 2045 | 2356 | 2143 | 2090 | 1919 | 1478 | |
| Those reporting MACEs | 360 | 458 | 393 | 371 | 326 | 207 | |
| No of redundant trials initiated after cut-off point: | |||||||
| All | 1731 | 2147 | 1864 | 1816 | 1602 | 1158 | |
| Those reporting MACEs | 272 | 390 | 309 | 294 | 230 | 156 | |
| No of redundant trials continued recruiting after cut-off point: | |||||||
| All | 314 | 209 | 279 | 274 | 317 | 320 | |
| Those reporting MACEs | 88 | 68 | 84 | 77 | 96 | 51 | |
| No of participants treated in control group: | |||||||
| All | 95 892 | 111 419 | 101 250 | 98 743 | 89 288 | 67 786 | |
| Those reporting MACEs | 22 380 | 27 271 | 23 845 | 23 149 | 20 486 | 14 555 | |
| No of person years treated in control group: | |||||||
| All | 17 318 | 22 049 | 18 760 | 18 083 | 15 508 | 10 480 | |
| Those reporting MACEs | 6766 | 9659 | 7530 | 7153 | 5840 | 3518 | |
| No of extra MACEs (95% CI): | |||||||
| Death | 559 (506 to 612) | 711 (652 to 772) | 609 (555 to 667) | 585 (530 to 640) | 491 (442 to 539) | 275 (238 to 310) | |
| New or recurrent myocardial infarction | 973 (897 to 1052) | 1292 (1198 to 1382) | 1085 (1000 to 1164) | 1029 (950 to 1110) | 845 (774 to 920) | 584 (524 to 648) | |
| Revascularization | 83 (58 to 105) | 130 (100 to 158) | 100 (73 to 125) | 93 (66 to 117) | 60 (40 to 78) | 16 (6 to 25) | |
| Heart failure | 398 (352 to 448) | 495 (442 to 546) | 422 (374 to 473) | 410 (362 to 459) | 364 (321 to 412) | 215 (183 to 251) | |
| Stroke | 161 (132 to 190) | 203 (170 to 236) | 176 (145 to 206) | 168 (137 to 198) | 148 (121 to 175) | 110 (88 to 132) | |
| Recurrent or deteriorated angina pectoris | 1197 (1110 to 1282) | 1560 (1459 to 1665) | 1305 (1216 to 1397) | 1253 (1164 to 1341) | 1050 (969 to 1131) | 683 (609 to 752) | |
| Unspecified MACEs | 99 (69 to 129) | 144 (111 to 177) | 100 (70 to 130) | 100 (70 to 130) | 93 (63 to 120) | 28 (9 to 45) | |
| Total MACEs | 3470 (3323 to 3619) | 4535 (4367 to 4702) | 3795 (3651 to 3955) | 3638 (3487 to 3789) | 3054 (2916 to 3185) | 1913 (1801 to 2014) | |
CMA=cumulative meta-analysis.