TABLE 1.
Summary statistics for maternal biomarkers, child outcomes at 7 years of age, and model covariates
| Variable | n | Mean (SD) | Minimum | Median | Maximum |
|---|---|---|---|---|---|
| Maternal prenatal biomarkers | |||||
| Hair MeHg, ppm | 1237 | 3.91 (3.47) | 0.01 | 2.89 | 31.66 |
| Total n-3 PUFA, mg/mL | 1237 | 0.27 (0.09) | 0.12 | 0.27 | 0.63 |
| Total n-6 PUFA, mg/mL | 1237 | 1.10 (0.29) | 0.42 | 1.09 | 2.70 |
| n-6:n-3 ratio | 1237 | 4.35 (1.64) | 1.55 | 3.95 | 15.80 |
| DHA, mg/mL | 1237 | 0.18 (0.08) | 0.04 | 0.18 | 0.52 |
| AA, mg/mL | 1237 | 0.20 (0.08) | 0.04 | 0.21 | 0.38 |
| Child 7-year outcomes | |||||
| Trailmaking time A | 1132 | 92.7 (42.1) | 27 | 64 | 300 |
| BNT total | 1229 | 23.2 (5.3) | 8 | 23 | 45 |
| CELF-5 total | 1200 | 81.7 (16.6) | 6 | 82 | 135 |
| CELF-5 FD | 1224 | 11.5 (4.1) | 0 | 11 | 24 |
| CELF-5 LC | 1231 | 17.7 (3.0) | 0 | 18 | 25 |
| CELF-5 RS | 1219 | 26.9 (7.7) | 3 | 26 | 57 |
| CELF-5 SC | 1222 | 19.5 (4.3) | 0 | 21 | 26 |
| CELF-5 USP | 1215 | 5.8 (3.5) | 0 | 3 | 18 |
| CBCL total | 1218 | 42.4 (24.3) | 0 | 25 | 191 |
| KBIT-2 word knowledge | 1233 | 20.4 (7.8) | 4 | 22 | 47 |
| KBIT-2 matrices | 1229 | 17.6 (4.9) | 0 | 16 | 33 |
| WJ-III applied problems | 1225 | 23.5 (3.7) | 0 | 24 | 34 |
| WJ-III letter word | 1224 | 52.8 (22.4) | 2 | 62 | 76 |
| FT dominant hand | 1222 | 31.2 (5.1) | 5 | 31.2 | 45.8 |
| FT nondominant hand | 1223 | 27.4 (4.6) | 4.2 | 27.4 | 46.4 |
| SCQ total | 1227 | 8.4 (4.3) | 0 | 9 | 31 |
| SRS-2 total | 1235 | 48.0 (19.3) | 6 | 46 | 129 |
| Covariates | |||||
| Child age at testing 7 years | 1237 | 7.4 (0.2) | 7 | 7.3 | 7.9 |
| SES at 7 years | 1237 | 33.3 (10.8) | 8 | 32 | 63 |
| Raw maternal KBIT-2 matrices | 1237 | 29.6 (7.0) | 4 | 30 | 46 |
| Mothers’ age at delivery | 1237 | 27.1 (6.3) | 16.3 | 26.1 | 46.8 |
| Child sex, female | 1237 | 48% | |||
| Family status at 7 years | |||||
| Both parents living with child | 1237 | 52% | |||
Total n-3 PUFA is defined as the sum of a-linolenic acid + EPA + DHA; Total n-6 PUFA is defined as the sum of linoleic acid + AA. Abbreviations: AA, arachidonic acid; BNT, Boston Naming Test; CBCL, Child Behavior Checklist; CELF-5, Clinical Evaluation of Language Fundamentals-5; FD, following directions; FT, finger tapping; KBIT-2, Kaufman Brief Intelligence Test 2; LC, linguistic concepts; MeHg, methylmercury; RS, recalling sentences; SC, sentence comprehension; SES, socioeconomic status; SCQ, Social Communication Questionnaire; SRS-2, Social Responsiveness Scale 2; USP, understanding spoken paragraphs; WJ-III, Woodcock-Johnson Test of Scholastic Achievement–III.