TABLE 2.
Prenatal methylmercury exposure in Models 1 and 2 in relation to child neurodevelopmental outcomes at 7 years of age: Seychelles Child Development Study Nutrition 2 Cohort
| Outcome | n | MeHg: Model 11 | MeHg: Model 22 | ||
|---|---|---|---|---|---|
| Beta, SE | P | Beta, SE | P | ||
| Log, Trailmaking time A | 1132 | 0.01, 0.01 | 0.26 | 0.02, 0.01 | 0.24 |
| Square root, BNT total | 1229 | 0.02, 0.02 | 0.15 | 0.02, 0.02 | 0.16 |
| CELF-5 total | 1200 | − 0.20, 0.49 | 0.68 | − 0.25, 0.48 | 0.61 |
| CELF-5 FD | 1224 | − 0.12, 0.13 | 0.35 | − 0.12, 0.13 | 0.33 |
| CELF-5 LC^2 | 1231 | − 0.71, 2.92 | 0.81 | − 1.06, 2.90 | 0.72 |
| CELF-5 RS | 1219 | − 0.09, 0.23 | 0.68 | − 0.11, 0.23 | 0.64 |
| CELF-5 SC^2 | 1222 | 0.52, 4.33 | 0.90 | 0.32, 4.30 | 0.94 |
| Square root, CELF-5 USP | 1215 | − 0.00, 0.02 | 0.90 | − 0.00, 0.02 | 0.84 |
| Square root, CBCL total | 1218 | − 0.01, 0.05 | 0.81 | − 0.01, 0.05 | 0.80 |
| KBIT-2 word knowledge | 1233 | − 0.28, 0.24 | 0.25 | − 0.30, 0.24 | 0.22 |
| KBIT-2 matrices | 1229 | 0.07, 0.15 | 0.63 | 0.06, 0.15 | 0.69 |
| WJ-III applied problems^2 | 1225 | 0.52, 5.00 | 0.92 | 0.32, 4.98 | 0.95 |
| WJ-III letter word | 1224 | − 1.36, 0.68 | 0.05 | − 1.39, 0.68 | 0.04 |
| FT dominant hand | 1222 | 0.00, 0.15 | 0.97 | 0.01, 0.15 | 0.96 |
| FT nondominant hand | 1223 | − 0.14, 0.14 | 0.33 | − 0.13, 0.14 | 0.33 |
| Square root, SCQ total | 1227 | − 0.05, 0.02 | 0.04 | − 0.05, 0.02 | 0.04 |
| Square root, SRS-2 total | 1235 | − 0.01, 0.04 | 0.86 | − 0.01, 0.04 | 0.83 |
A regression analysis was performed for each outcome separately. Beta indicates the estimated regression coefficients. B and SE values are expressed as changes in outcomes per IQR increase in exposure (3.75 ppm). The P values have not been adjusted for multiple comparisons. P values are considered statistically significant when P < 0.0029. Abbreviations: AA, arachidonic acid; BNT, Boston Naming Test; CBCL, Child Behavior Checklist; CELF-5, Clinical Evaluation of Language Fundamentals–5; FD, following directions; FT, finger tapping; KBIT-2, Kaufman Brief Intelligence Test 2; LC, linguistic concepts; MeHg, methylmercury; RS, recalling sentences; SC, sentence comprehension; SCQ, Social Communication Questionnaire; Sqrt, SCQ total score; SRS-2, Social Responsiveness Scale 2; USP, understanding spoken paragraphs; WJ-III, Woodcock-Johnson Test of Scholastic Achievement–III.
Model 1 was adjusted for maternal DHA and AA status, maternal age, maternal IQ, child age, child sex, Hollingshead socioeconomic status, and family status. CELF-5 outcomes are also adjusted for interviewer. Effect estimates for covariates are shown in Supplemental Table 1.
Model 2 was adjusted for maternal n-6:n-3 ratio, maternal age, maternal IQ, child age, child sex, Hollingshead socioeconomic status, and family status. CELF-5 outcomes are also adjusted for interviewer.