FIGURE 6:

ALS-mutant FUS forms cytoplasmic droplets; phosphomimetic substitutions in the prion-like domain do not alter droplet dynamics. (A) Representative images of FUS(494)-GFP phosphomimetic constructs 24 h posttransfection. (B) Average number of large (>1 m²) or small (<1 m²) FUS(494)-GFP cytoplasmic granules per cell 24 h posttransfection; error bars represent SEM (n = 17). (C) FRAP half-times of FUS(494)-GFP 24 h posttransfection; error bars represent 95% CI (n = 30). Student’s t test was used for statistical analysis.