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. 2021 Feb 1;14:23. doi: 10.1186/s13048-020-00760-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — SERBP1 is a direct target of miR-362-3p. a Nineteen target genes that can bind to miR-362-3p were selected using three online bioinformatics prediction software programs (TargetScan, miRWalk, and miRTarBase). b Putative wild-type (WT) and mutant-type (MUT) miR-362-3p target sequences of SERBP1 mRNA 3’ UTRs. c, d SERBP1 mRNA and protein expression in ovarian cancer cell lines are upregulated compared to that in normal ovarian epithelium cell lines. e Relative luciferase activity in ovarian cancer cells cotransfected with constructs carrying wild-type or mutant SERBP1 mRNA 3’ UTRs with the miR-362-3p mimic. f-i Effects of miR-362-3p mimic and inhibitor on SERBP1 mRNA and protein expression in ovarian cancer cells, respectively. Data are shown as the means ± SDs. *P < 0.05