Fig. 2.

Evidence that stopping stimulation impairs heterosynaptic metaplasticity. a An experiment performed as in Fig. 1b, except that stimulation was paused on both inputs for 10 min following the 2nd TBS and 20 min following the 3rd TBS (n = 9). b An experiment performed as in Fig. 1b, except that stimulation on both inputs was paused for 20 min following the wTBS (n = 12). c Superimposition of the LTP induced by the wTBS illustrated in a, Fig. 1a, b. d Superimposition of the LTP induced by the wTBS illustrated in b, Fig. 1a, b. e Quantification of the level of LTP induced by the sTBS for these experiments, 120 min post sTBS. f Quantification of the level of LTP induced by the wTBS for these experiments, 90 min post wTBS. *p < 0.05, **p < 0.01, ***p < 0.001, comparisons vs. sTBS