Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Feb 1;40:52. doi: 10.1186/s13046-021-01857-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 5 — LINC00460 mediated regulation of HMGA1 mRNA stability. a, b Effect of LINC00460 KD or OE on the expression of IGF2BP2, DHX9 and HMGA1 protein level in HCT116 and SW480 cells, as assessed by Western blot. c, d, e, f Relative mRNA expression levels of LINC00460, IGF2BP2, DHX9 and HMGA1 in HCT116 and SW480 cells ± LINC00460 KD/OE (*p < 0.05, **p < 0.01, ***p < 0.001). g, h Western blot assay was performed to measure DHX9, IFG2BP2 and HMGA1 protein level after transfection of DHX9/IGF2BP2 siRNA, control siRNA in LINC00460 overexpressed CRC cells. i, j, k, l RIP assay shows interaction declined between HMGA1 and DHX9/IGF2BP2 after knockdown of LINC00460 in CRC cells