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. 2020 Oct 1;31(21):2315–2330. doi: 10.1091/mbc.E20-04-0252

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© 2020 Bancroft, Holder, Geraghty, et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License.

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FIGURE 5: — PP1α/γ are required for rapid cyclin B destruction downstream of the spindle checkpoint. (A–C) HeLa CCNB1-mCherry GFP-Mad2 cells treated with (A) control, (B) siPP1α/γ, or (C) siPP2A-B55 for 60 h were imaged for 12 h at 2 min intervals. DNA was visualized with SiR-DNA. (D) Quantitation of the CCNB1 levels of individual cells shown in A. (E) The CCNB1 signal remaining at 50 min in siControl, siPP1α/γ, or siPP2A-B55 was plotted as mean ± SD (siControl n = 10, siPP1α/γ n = 8, siPP2A-B55 n = 9). *** denotes p < 0.001; **** denotes p < 0.0001.