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PP2A-B56, PP1, and PP2A-B55 dephosphorylate CDC20 at different points in the cell cycle. Schematic drawing illustrating the dephosphorylation of CDC20 by the three main mitotic phosphatases PP2A-B56, PP1α/γ, and PP2A-B55 in early mitosis, at the metaphase-to-anaphase transition and in anaphase, respectively. In this schematic, PP2A-B56 refers to the pool docked to the checkpoint protein BUBR1. Other pools of PP2A-B56 are active in anaphase.
