Fig. 2.

Combination index (CI) evaluation shows that INI-43 and cisplatin combination treatment results in a synergistic anti-cancer effect in SiHa cells. a Cells were subjected to INI-43, cisplatin or the combination treatment for 48 h. Combination treatments were carried out at fixed INI-43-to-cisplatin ratios of 1:3, 1:4 and 1:5 (see Table S1). Viable cells were determined using the MTT assay and expressed relative to untreated. Arrows indicate enhanced cell death. b CI values were calculated using CompuSyn software and plotted against the fraction affected. Data shown are the mean ± SEM (n = 5) and experiments were repeated at least two independent times