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. 2021 Feb 2;19:16. doi: 10.1186/s12958-020-00690-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Effects of a CB1 receptor antagonist and agonist on the proliferation of JZSMCs. a JZSMCs were treated with the CB1 receptor antagonist AM251 at different concentrations, and the cell survival rates were analysed. b Inhibition effect of AM251 at different concentrations on adenomyotic JZSMCs. The X axis corresponds to the 50% inhibition rate (the logarithm (base ten) of the half maximal inhibitory concentration (IC50)). c The cell survival rates after incubation with the CB1 receptor agonist ACEA at different concentrations are shown. d Comparison of the cell survival rates after incubation with different drugs. Three independent experiments were conducted for each treatment. One representative image from each group of three experiments is shown (Log₁₀ M is the logarithm of the molar concentration to 10, * P < 0.05; ** P < 0.01, ***, P < 0.001, ****, P < 0.0001)