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. 2021 Feb 1;9:19. doi: 10.1186/s40478-021-01119-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Reduction of Nlgn1 levels in temporal cortex of sporadic and familial AD cases. a Representative Western blot and relative GAPDH signal. Fifteen µg proteins per well of TBS soluble fractions of patients with sAD (n = 9), fAD (n = 9), PA (n = 15) and healthy Ctrl (n = 7) were separated by SDS-PAGE (4–12%) under reducing conditions. Neuropathological classification was based on Thal phases, Braak staging and CERAD score. A calibration curve was created using recombinant Nlgn1 extracellular domain fusion protein, to estimate the amount of Nlgn1 present in the samples. Samples were run on duplicate blots. b The box plots present the median and the interquartile range, the whiskers show the minimum and the maximum values. Significance: p ≤ 0.05. WB = Western blot