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. 2021 Feb 1;9:19. doi: 10.1186/s40478-021-01119-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Nlgn1 level changes in relation to pathological classification. a Nlgn1 levels (as presented in Fig. 2) categorized by Braak stages (Braak 0, NFTs score 0, Braak I-II, transentorhinal; Braak III-IV, limbic; Braak V-VI, isocortical) b Nlgn1 levels classified based on Thal phases (Thal 0 = no amyloid; Thal 1–2 = isocortical; Thal 3 = basal ganglia; Thal 4 = forebrain and midbrain; Thal 5 = medulla oblongata and cerebellum). c Nlgn1 levels categorized by CERAD, neuritic plaques score (0 = none, 1 = sparse, 2 = moderate, 3 = frequent). d Nlgn1 levels categorized by ApoE allele ε4 carriers. In the box plots, median and interquartile range are represented by the box; whiskers represent the minimum and maximum values. In graph d, horizontal lines in the scatterplot represent median and interquartile range. Significance: p ≤ 0.05