Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Feb 1;9:19. doi: 10.1186/s40478-021-01119-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 5 — Nlgn1 levels do not differ in CSF of AD patients as compared to controls. Western blot analysis of Nlgn1 levels in CSF samples of AD (n = 43) and Ctrl (n = 42) individuals. Nlgn1 band was normalized using recombinant Nlgn1 to correct for inter-gel variation. a Representative Western blot. b Clinically characterized Ctrl and AD group c dichotomized Aβ_42/40–negative (Aβ-) and Aβ_42/40–positive (Aβ +) groups d AD biologically defined groups based on t-tau (cut-off = 460 pg/ml), p-tau (cut-off = 58.3 pg/ml) and Aβ_42/40 (cut-off = 0.0934 pg/ml). The horizontal lines represent the median and interquartile range. Significance: p ≤ 0.05. e Correlation between CSF Nlgn1 levels and t-tau (left, Spearman´s rho = 0.547) and neurogranin (Ng) (right, Spearman´s rho = 0.512). Dashed lines represent the 95% confidence bands of the best-fit line