Table 1.

Genome-wide expression profiling of RNA from skin of CCN1-deficient and control skin reveals that clusters involved with cell migration, adhesion and transcription are affected by loss of CCN1 (fold change reflects decrease in expression in response to loss of CCN1). For entire lists of mRNAs affected greater or equal to 1.5-fold by loss of CCN1, please see Supplemental information.

ID	Gene name	Fold change
Cell migration cluster
NM_010415	Heparin-binding EGF-like growth factor	−2.2867
NM_001139509	Nuclear receptor subfamily 4, group A, member 2	−1.92135
NM_013749	Tumor necrosis factor receptor superfamily, member 12a	−1.8584
Cell adhesion cluster
NM_133743	Ly6/Plaur domain containing 3	−1.52012
NM_010516	Cysteine rich protein 61	−1.60192
NM_053110	Glycoprotein (transmembrane) nmb	−1.60465
NM_010577	Integrin alpha 5 (fibronectin receptor alpha)	−1.57323
NM_001081445	Neural cell adhesion molecule 1	−1.53712
NM_009398	Similar to TNF-stimulated gene 6 protein; tumor necrosis factor alpha induced protein 6	−2.20598
NM_011580	Thrombospondin 1; similar to thrombospondin 1	−2.18805
NM_013749	Tumor necrosis factor receptor superfamily, member 12a	−1.8584
Regulation of transcription cluster
NM_008036	FBJ osteosarcoma oncogene B	−2.38818
NM_007498	Activating transcription factor 3	−2.07292
NM_153287	Cysteine-serine-rich nuclear protein 1	−1.72143
NM_007950	Epiregulin	−2.12905
NM_010235	Fos-like antigen 1	−2.6796
NM_010212	Four and a half LIM domains 2	−1.5412
NM_010849	Myelocytomatosis oncogene	−1.58666
NM_008719	Neuronal PAS domain protein 2	−1.64826
NM_010444	Nuclear receptor subfamily 4, group A, member 1	−2.583
NM_001139509	Nuclear receptor subfamily 4, group A, member 2	−1.92135
NM_027787	Regulatory factor X, 2 (influences HLA class II expression)	−2.14973
NM_017373	Similar to NFIL3/E4BP4 transcription factor; nuclear factor, interleukin 3, regulated	−1.66494