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. 2019 Feb 21;1:100001. doi: 10.1016/j.mbplus.2018.11.001

Fig. 3.

Fig. 3

Group 1: C. elegans collagens with orthologues in vertebrates.

(A) Collagen type IV. Alignment of collagen type IV α1 from Homo sapiens with EMB-9 and LET-2 from Caenorhabditis elegans.

(B) Phylogenetic analysis of collagen type IV. The C-terminal collagen type IV domains (C4) of humans and C. elegans were analyzed using ClustalO [70] followed by Neighbor Joining. The numbers indicate the bootstrap values of 100 replicates. The nematode-specific sequences are indicated in bold (EMB-9 and LET-2).

(C) Endostatins. Comparison of CLE-1 from C. elegans with endostatin-containing collagens type XV and XVIII from H. sapiens. Asterisk (*) indicate domain predictions with weak significance.

(D) Transmembrane collagens. Comparison of C. elegans COL-99, the only non-cuticular transmembrane collagen, with its human orthologues (collagens type XIII, XXIII, XXV). For human proteins, dark outlines group collagenous stretches recognized as collagen domains in earlier publications. All panels are drawn to scale. Colour codes are as follow: light blue: signal peptides; pink: transmembrane region; orange: frizzled domain or collagen C4 domain; yellow: Laminin G-like domain; purple: endostatin domain; blue: collagenous Gly-X-Y repeats.