Table 2.
GeneWalk identifies transcriptional regulators among highly connected genes with many significant functions in the JQ1 condition
| Gene (ranked by connectivity with other genes) |
Most relevant biological process annotation (GeneWalk with Pathway Commons knowledge base) |
Gene has any significant transcription-related annotations (FDR = 0.125)? |
|---|---|---|
| FOXO4 | Positive regulation of transcription by RNA polymerase II | Yes |
| CTNNB1 | Canonical Wnt signaling pathway involved in negative regulation of apoptotic process | Yes |
| MYB | Positive regulation of transcription by RNA polymerase II | Yes |
| RUNX1 | Hemopoiesis | Yes |
| GABPB2 | Positive regulation of transcription by RNA polymerase II | Yes |
| CDKN1A | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | INDRA only |
| PPARG | Response to lipid | Yes |
| TFAP4 | Positive regulation of transcription | Yes |
| VCL | Platelet aggregation | No |
| TFDP2 | Positive regulation of transcription by RNA polymerase II | Yes |
| RUNX2 | Hemopoiesis | Yes |
| CDC5L | Positive regulation of transcription by RNA polymerase II | Yes |
| DICER1 | Conversion of ds siRNA to ss siRNA involved in RNA interference | No |
| RREB1 | Positive regulation of transcription by RNA polymerase II | Yes |
| TAL1 | Positive regulation of transcription by RNA polymerase II | Yes |
| MRE11 | Double-strand break repair via nonhomologous end joining | No |
| ELOVL6 | Fatty acid elongation, saturated fatty acid | INDRA only |
| EPAS1 | Cellular response to hypoxia | Yes |
| EDNRA | Artery smooth muscle contraction | INDRA only |
| SUPT16H | DNA replication-independent nucleosome organization | Yes |
| HIST2H2AC | Chromatin organization | No |