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[Preprint]. 2021 Jan 26:2021.01.21.21249203. [Version 1] doi: 10.1101/2021.01.21.21249203

Figure 1. Structures of SARS-CoV-2 spike-biliverdin (A,B) and spike-P008_056 Fab (C) complexes.

Figure 1.

(A) Cryo-EM 3D reconstructions of trimeric SARS-CoV-2 spike ectodomain in 3RBD-down (left) and 1RBD-up (right) conformations determined under saturation with biliverdin. Spike protomers are color-coded. Biliverdin and glycans are shown in green and grey, respectively. (B) Details of the biliverdin binding pocket in the crystal structure. SARS-CoV-2 NTD is shown as cartoons with selected amino acid residues and biliverdin in sticks. Carbon atoms of the protein chain, sugars (NAG), and biliverdin are in purple, grey and green, respectively; the remaining atoms are coloured as follows: oxygen, red; nitrogen, blue; and sulphur, yellow. Dark grey dashes are hydrogen bonds.