Figure 4. Cryo-EM structure of the spike-Fab complex.
(A) Reconstruction obtained with multibody refinement in Relion (left) and a zoom on the spike-Fab interface in the structure obtained by consensus refinement (Fig. S11d). (B) Refined model of the spike-Fab complex shown as cartoon, with selected amino acid side chains in sticks and indicated. Carbon atoms of the gate and lip NTD elements that relocate to allow Fab binding (arrows), are shown in black. Fab heavy (HV) and light (LV) chains are shown in blue and beige, respectively.