Table 1.
Predicted CTL epitopes with MHC I binding epitopes against human emerging pathogenic SARS-CoV, MERS-CoV, and SARS-CoV-2.
Selected Antigen | Organism | Position | CTL epitope | MHC-I epitope | Allele | Percentile rank |
---|---|---|---|---|---|---|
nsp3 | SARS-CoV-2 | 829-840 | LNHTKKWKY | MSALNHTKKWKY | HLA-B*57:01 | 0.26 |
SARS-CoV | 1184-1195 | FEVLAVEDT | FEVLAVEDTQGM | HLA-A*26:01 | 0.62 | |
MERS-CoV | 391-402 | SFDYLIREA | AVSFDYLIREAK | HLA-A*11:01 | 0.32 | |
nsp8 | SARS-CoV-2 | 12-23 | YAAFATAQE | YAAFATAQEAYE | HLA-B*35:01 | 0.21 |
SARS-CoV | 35-46 | KKLKKSLNV | LKKLKKSLNVAK | HLA-A*03:01 | 2.10 | |
MERS-CoV | 39-50 | AVNIAKNAY | LQKAVNIAKNAY | HLA-B*15:01 | 0.52 | |
S protein | SARS-CoV-2 | 27-38 | YTNSFTRGV | AYTNSFTRGVYY | HLA-A*01:01 | 0.04 |
SARS-CoV | 454-465 | ISNVPFSPD | DISNVPFSPDGK | HLA-A*11:01 | 1.40 | |
MERS-CoV | 303-314 | IQSDRKAWA | IQSDRKAWAAFY | HLA-A*01:01 | 0.11 | |
M protein | SARS-CoV-2 | 185-196 | RVAGDSGFA | QRVAGDSGFAAY | HLA-A*30:02 | 0.06 |
SARS-CoV | 53-64 | LWLLWPVTL | LWLLWPVTLACF | HLA-A*23:01 | 0.32 | |
MERS-CoV | 152-163 | HFGACDYDR | GMHFGACDYDRL | HLA-B*38:01 | 0.49 | |
N protein | SARS-CoV-2 | 45-56 | NNTASWFTA | LPNNTASWFTAL | HLA-B*07:02 | 0.40 |
SARS-CoV | 62-73 | EELRFPRGQ | KEELRFPRGQGV | HLA-C*07:01 | 1.40 | |
MERS-CoV | 249-260 | HKRTSTKSF | KMRHKRTSTKSF | HLA-A*03:01 | 0.80 | |
Eprotein | SARS-CoV-2 | 33-44 | TALRLCAYC | ILTALRLCAYCC | HLA-A*25:01 | 1.40 |
SARS-CoV | 50-61 | VKPTVYVYS | SLVKPTVYVYSR | HLA-A*31:01 | 0.87 | |
MERS-CoV | 49-60 | VQPALYLYN | TLLVQPALYLYN | HLA-A*29:02 | 1.30 |