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. 2020 Apr 21;6-7:100036. doi: 10.1016/j.mbplus.2020.100036

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© 2020 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 3 — Predominant disc degeneration phenotypes and their ECM signatures. Each degenerative sub-type is characterized by a unique extracellular matrix composition and remodeling signature. Red (increase) and blue (down) arrows represent directionality of the change respectively. Abbreviations: collagen (COL); proteoglycans (PGs); tissue non-specific alkaline phosphatase (TNAP); metalloproteases (MMP); A Disintegrin and Metalloproteinase with Thrombospondin motifs (ADAMTS); aggrecan (ACAN); progranulin (PGRN); ATP-binding cassette sub-family C member 6 (ABCC6); aggrecanase (ADAMTS-1, -4 & -5)-generated N-terminal neoepitope ARG after cleavage (ARGxx); Nucleus pulposus (NP); Annulus fibrosis (AF).