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. 2020 Oct 2;6(40):eabb5223. doi: 10.1126/sciadv.abb5223

Fig. 1. Characterization of nMOFs.

Fig. 1

(A) Schematic illustration of controlled synthesis of Hf-DBB-Ir and Hf-DBBF-Ir nMOFs based on Hf-oxo clusters and DBBF-Ir or DBB-Ir ligands, respectively. Upon x-ray irradiation, Hf-oxo clusters absorb x-ray to generate •OH through radiolysis and transfer energy to adjacent photosensitizing ligands to generate 1O2 and/or O2−. (B) TEM images of Hf-DBB-Ir (top) and Hf-DBBF-Ir (bottom).. Scale bars, 100 nm. (C to E) •OH generation probed by aminophenyl fluorescein (APF) with an IVIS fluorescence imaging system (n = 6) (C), 1O2 generation probed by SOSG with an IVIS fluorescence imaging system (n = 6) (D), and O2− generation probed by 5-tert-butoxycarbonyl 5-methyl-1-pyrroline-N-oxide (BMPO) in electron paramagnetic resonance (EPR) (E) of DBB-Ir, DBBF-Ir, Hf-DBB-Ir, or Hf-DBBF-Ir upon x-ray irradiation. a.u., arbitrary units; G, gauss.