Figure 4.

IFN-γ response to SARS-CoV-2 glycoprotein S of peripheral blood mononuclear cells of participants who received two doses of vaccine (n=44) or placebo (n=14)

Dots show individual datapoints of intact (unstimulated) cells and cells stimulated with SARS-CoV-2 glycoprotein S (antigen stimulated). Horizontal lines show median values, whiskers show 95% Cl. The threshold of detection (<2 pg/mL) is indicated with the grey shaded area. The grey lines connecting dots between unstimulated and antigen-stimulated cells show changes in IFN-γ response in some representative individuals. *p<0·0001 for day 28 antigen-stimulated cells versus day 1 antigen-stimulated cells, in the vaccine group.