Figure S19.

Changes in twitch tension predicted by the five-state model for change in ${\mathit{k}}_{\mathbf{-}\mathbf{A}}$ up to 24-fold from those used in Fig. 3 (dark green line), denoted as orig. ${\mathit{k}}_{\mathbf{-}\mathbf{A}}^{\mathbf{o}}\mathbf{.}$ The main effect of changes in $k_{-A}^o$ on the tension responses are displayed as changes in the peak tension, resting tension, and the rate of tension rise. There are two distinctive regions in the peak and resting tensions: (1) the peak tensions modestly decrease for $k_{-A}^o$ increase up to twofold and resting tension decreases for $k_{-A}^o$ increase up to fourfold; and (2) for larger increases in $k_{-A}^o\mathrm{,}$ the peak tension rapidly falls, and resting tension reaches very low levels. Similarly, the rate of tension relaxation increases for $k_{-A}^o$increase up to fourfold and then decreases. The superscript o is omitted from the figure axis label for clarity.