Table 2. Comparison of parameters for the twitch contraction simulations with the six-state model (including PS) of isometric half-sarcomere (Figs. 3, S2, and S4) and trabeculae at fixed length Fig. 5, A and B, and Fig. 6 A.

		Isometric HS		Fixed-length trabeculae
XB cycle	Parameter	22°Ca	27.2°Cb	22°Ca,c	27.2°Cb,c	30°Cc
Myosin–actin binding rate	${k_{\mathrm{+}}^o}_A$	72	125	140	226	256
Myosin–actin detachment rate	$k_{-A}^o$	10	21	22	46	66
Power stroke Gibbs energy change	$\Delta G_{stroke}$	−15.3	−15.3	−13	−13	−13
ADP release rate	$k_{+D}^o$	40	60	40	60	92

Displayed are only parameters that are different from those shown in Table 1. Rates ${k_{+}^o}_A,$ $k_{-A}^o,$ and $k_{+D}^o$ are per second; $\Delta G_{stroke}$ is in units of k_BT. HS, half-sarcomere; XB, cross-bridge.

^aJanssen and de Tombe (1997).

^bCaremani et al. (2016).

^cJanssen et al. (2002) at slightly different temperatures of 22.5°C and 27.5°C; the rate $k_{\mathrm{+A}}^o$ is slightly higher, 149 s⁻¹ at 22.5°C.