Figure 1.

Mutations can be grouped into bins based on the biophysical consequences of the initial molecular insult that drives the disease pathogenesis. Colored boxes represent potential biophysical bins for organizing mutations. White boxes represent broad bins that we subdivided into more specialized bins to describe the effects of sarcomeric mutations. While these bins are neither mutually exclusive nor exhaustive, they provide a useful framework for classifying patient subpopulations and for identifying biophysical parameters that can be targeted pharmacologically for the development of precision therapeutics for these subpopulations.