Fig. 1.

The role of hepatic macrophages in liver diseases. Schematic overview of the roles of Kupffer cells and monocyte-derived macrophages in liver disease. CCL C-C chemokine ligand, CTGF connective tissue growth factor, DAMP damage-associated molecular pattern, HGF hepatocyte growth factor, HSC hepatic stellate cell, IGF insulin-like growth factor, IL interleukin, MMP matrix metallopeptidase, MoMϕ monocyte-derived macrophages, PAMP pathogen-associated molecular pattern, PDGF platelet-derived growth factor, TGF transforming growth factor, TNF tumor necrosis factor, VEGF vascular endothelial growth factor