Fig. 2.

Macrophage-based therapeutic approaches for liver disease. Schematic overview of the different therapeutic approaches that focus on the inflammatory system divided into those that hamper inflammatory cell recruitment, those that inhibit macrophage action, and those that shape macrophage function and polarization. ASK-1 apoptosis signal-regulating kinase 1, PPAR peroxisome proliferator-activated receptor, CCL C-C chemokine ligand, CCR C-C chemokine receptor