Table 2.

PV-IN alterations in Alzheimer’s disease and associated animal models.

PV alteration	Described in	References
Reduced number of PV-INs in hippocampus	Animal model	[33]
Increased number of PV-INs in hippocampus	Animal model	[35]
Reduced number of PV-INs in parasubiculum	Animal model	[33]
Increased number of PV-INs in piriform cortex	aAD	[38]
Reduced septohippocampal pathway synapse density on PV-INs	Animal model	[22]
PV-INs exhibit more depolarized resting membrane potentials and smaller action potential amplitudes	Animal model	[26]
Reduced hippocampal gamma power	Animal model	[21]
Reduced gamma activity	Animal model	[22, 26]
Impaired theta-gamma oscillation phase-amplitude cross-frequency coupling	Animal model	[23]
Disrupted evoked gamma oscillations to auditory stimuli	Animal model	[23]
Decreased number of neurons with intact perineuronal nets	AD	[37]

^aAD Alzheimer’s disease, human subject study.