Table 1.

A variety of stress-types induce PUMA- and BAX-dependent neuronal apoptosis in vitro.

Stress type	Stressor	PUMA and/or BAX dependent	Neuron type	Species	Publication
Oxidative stress	Hydrogen peroxide, 1-methyl-4-phenylpyridinium, TBH, NOC-12	PUMA and BAX	Cortical	Mouse (C57BL/6)	Steckley et al. [35]
	Hydrogen peroxide	PUMA	Cortical	Mouse (C57BL/6)	Baxter et al. [121]
	Hydrogen peroxide	PUMA	Cortical	Mouse (C57BL/6)	Fricker et al. [122]
	6-OHDA	PUMA	Dopaminergic	Mouse (CF-1)	Bernstein et al. [34]
	1-methyl-4-phenylpyridinium	PUMA	Dopaminergic	Mouse (CF-1)	Bernstein and O’Malley [132]
	6-OHDA	BAX	Dopaminergic	Mouse (C57BL/6)	Kim et al. [123]
ER stress	Thapsigargin, tunicamycin	PUMA	Cortical	Mouse (C57BL/6)	Galehedar et al. [65]
	Tunicamycin	PUMA	Telencephalic	Mouse (C57BL/6)	Ghosh et al. [66]
	Tunicamycin	BAX	Superior cervical ganglia	Mouse (C57BL/6)	Smith et al. [124]
	Tunicamycin	PUMA	Cortical	Mouse (C57BL/6)	Concannon et al. [125]
	Thapsigargin, tunicamycin	PUMA	Cortical	Mouse (C57BL/6)	Fricker et al. [122]
	Tunicamycin	PUMA	Motor neuron	Mouse (C57BL/6)	Kieran et al. [32]
DNA damage	Camptothecin	PUMA	Cortical	Mouse (C57BL/6)	Uo et al. [126]
	Camptothecin, etoposide	PUMA	Cortical	Mouse (C57BL/6)	Galehedar et al. [65]
	10 Gy irradiation	BAX	Cerebral granule neural precursor	Mouse (C57BL/6)	Crowther et al. [56]
	Camptothecin, cisplatin, etoposide	PUMA	Cortical	Mouse (C57BL/6)	Fricker et al. [122]
	Cytosine arabinoside	PUMA and BAX	Superior cervical ganglia	Wistar rat	Wyttenbach et al. [68]
Environmental toxin	Sodium arsenite, okadaic acid	PUMA	Cortical	Mouse (C57BL/6)	Fricker et al. [122]
Proteasomal inhibition	Epoxomicin, bortezomib	PUMA	Cortical	Mouse (C57BL/6)	Tuffy et al. [70]
Stroke-like stress	Oxygen and glucose deprivation	BAX	Cortical	Mouse (C57BL/6)	D’Orsi et al. [37]
Trophic-factor deprivation	Potassium deprivation	PUMA	Cerebellar granule	Mouse (C57BL/6)	Ren et al. [75]
	Potassium deprivation	PUMA	Cerebellar granule	Mouse (C57BL/6)	Ambacher et al. [71]
	Nerve growth factor deprivation	BAX	Superior cervical ganglia	Mouse (C57BL/6)	Deckwerth et al. [7]
Kinase inhibition	Staurosporine	BAX	Superior cervical ganglia	Rat	Deshmukh et al. [127]
	Staurosporine	PUMA	Cortical	Mouse (C57BL/6)	Léveillé et al. [130]
Death receptor	Tumor necrosis factor alpha	PUMA and BAX	Neural precursor cell	Mouse (C57BL/6)	Guadagno et al. [131]