Table 2.
Total retinal thickness between groups.
| Total retinal thickness | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Inner ring | Outer ring | |||||||||
| S | I | N | T | S | I | N | T | |||
| 6 months | APPNL−F/NL−F | Mean | 250.60 | 244.20 | 241.40 | 243.00 | 254.20 | 243.80 | 246.20 | 244.40 |
| SD | 5.73 | 4.82 | 4.28 | 4.53 | 6.38 | 4.44 | 5.63 | 2.41 | ||
| WT | Mean | 249.43 | 249.43 | 246.00 | 247.43 | 256.57 | 253.57 | 248.86 | 253.00 | |
| SD | 6.02 | 7.30 | 4.28 | 7.25 | 8.28 | 9.11 | 6.18 | 6.11 | ||
| P-value | 0.935 | 0.255 | 0.101 | 0.221 | 0.684 | 0.061 | 0.624 | 0.028* | ||
| 9 months | APPNL−F/NL−F | Mean | 252.36 | 247.29 | 247.43 | 247.57 | 257.71 | 245.36 | 251.21 | 246.14 |
| SD | 8.42 | 7.24 | 5.26 | 5.56 | 6.78 | 9.43 | 4.51 | 6.68 | ||
| WT | Mean | 257.17 | 250.33 | 250.50 | 251.83 | 261.67 | 249.00 | 248.17 | 252.33 | |
| SD | 7.31 | 6.12 | 6.92 | 7.68 | 11.38 | 5.37 | 7.36 | 7.12 | ||
| P-value | 0.246 | 0.342 | 0.230 | 0.185 | 0.282 | 0.535 | 0.320 | 0.063 | ||
| 12 months | APPNL−F/NL−F | Mean | 253.00 | 246.56 | 245.56 | 246.33 | 257.22 | 246.11 | 247.67 | 246.22 |
| SD | 8.38 | 3.17 | 5.96 | 5.70 | 11.29 | 4.86 | 4.85 | 7.07 | ||
| WT | Mean | 255.86 | 252.86 | 249.71 | 250.71 | 258.14 | 252.57 | 250.14 | 250.57 | |
| SD | 6.94 | 7.84 | 7.04 | 6.92 | 6.31 | 7.61 | 6.87 | 5.53 | ||
| P-value | 0.366 | 0.089 | 0.202 | 0.123 | 0.560 | 0.100 | 0.243 | 0.110 | ||
| 15 months | APPNL−F/NL−F | Mean | 253.83 | 248.00 | 244.83 | 249.17 | 257.50 | 247.00 | 248.17 | 247.67 |
| SD | 4.96 | 7.90 | 2.48 | 8.64 | 9.12 | 7.75 | 4.36 | 9.58 | ||
| WT | Mean | 252.71 | 254.86 | 251.00 | 250.57 | 257.29 | 255.29 | 250.71 | 251.57 | |
| SD | 7.11 | 5.90 | 6.68 | 8.48 | 9.23 | 6.34 | 6.05 | 6.11 | ||
| P-value | 0.429 | 0.044* | 0.031* | 0.473 | 0.617 | 0.038* | 0.418 | 0.195 | ||
| 17 months | APPNL−F/NL−F | Mean | 255.38 | 250.25 | 251.63 | 248.25 | 257.75 | 252.88 | 255.00 | 248.13 |
| SD | 7.48 | 4.37 | 5.73 | 3.37 | 9.10 | 5.30 | 7.48 | 4.52 | ||
| WT | Mean | 252.29 | 244.71 | 243.00 | 246.71 | 255.00 | 245.00 | 243.71 | 249.71 | |
| SD | 4.68 | 4.57 | 4.73 | 3.20 | 8.50 | 5.45 | 3.30 | 4.68 | ||
| P-value | 0.450 | 0.036* | 0.024* | 0.415 | 0.602 | 0.023* | 0.004** | 0.523 | ||
| 20 months | APPNL−F/NL−F | Mean | 240.83 | 241.83 | 239.08 | 240.25 | 245.25 | 244.91 | 242.58 | 241.67 |
| SD | 6.86 | 4.53 | 5.74 | 4.75 | 8.67 | 7.49 | 7.14 | 6.96 | ||
| WT | Mean | 250.67 | 253.17 | 251.50 | 251.50 | 255.33 | 252.33 | 249.50 | 252.00 | |
| SD | 9.87 | 8.38 | 8.89 | 8.80 | 9.54 | 8.14 | 6.75 | 9.61 | ||
| P-value | 0.054 | 0.007** | 0.009** | 0.007** | 0.039 | 0.076 | 0.100 | 0.031 | ||
*
in bold: p-value <0.05;
**
in bold: p-value <0.01;
Mann-Whitney U Test; WT, wild type; SD, standard deviation; S, superior; I, inferior; N, nasal; T, temporal.