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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Toxicol Lett. 2020 Dec 5;338:21–31. doi: 10.1016/j.toxlet.2020.12.005

Figure 2:

Figure 2:

Effect of superoxide scavenging in mitochondria or cytosol on JNK activation and GSH levels after APAP overdose. Mice were pre-treated with 100 mg/kg TEMPO or 20 mg/kg Mito-TEMPO 1 hour prior to 300 mg/kg APAP and sacrificed after 1 or 3 hours. (A) Western blots and (B) densitometry examining JNK activation after superoxide scavenging. (C) Total GSH levels in mice treated with APAP±TEMPO or Mito-TEMPO. Data are given as mean ± SEM, n=4; *p≤0.05 compared to APAP treatment alone.