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. 2021 Jan 28;27(4):305–320. doi: 10.3748/wjg.v27.i4.305

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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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PNPLA3 and genetic associations with laboratory measurements in genome-wide association studies and phenome-wide association studies. The score for the associations ranges from 0 to 1, with higher scores indicating stronger evidence for an association. Bubbles in the figure represent the different scores with varying shades of blue: the darker the blue, the stronger the association. Red arrows highlight the association of the rs738409 variant in PNPLA3 and laboratory measurements related with hematological traits. HDL: High density lipoprotein cholesterol; FEV: The ratio of forced expiratory volume to forced vital capacity, used as a measure of pulmonary function; uric: Uric acid; AST: Aspartate aminotransferase level; ALT: Alanine aminotransferase level; total chol: Total cholesterol. Source: Open Target Database (https://genetics.opentargets.org/gene/ENSG00000100344). Score summaries: Data sources and factors that affect the relative strength of the evidence scores can be found at: https://docs.targetvalidation.org/getting-started/scoring.