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. 2021 Jan 28;27(4):305–320. doi: 10.3748/wjg.v27.i4.305

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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Overrepresentation analysis of biological pathways of genes associated with platelet count vs. genes associated with nonalcoholic fatty liver disease. Overrepresentation analysis of biological pathways of platelet count-associated genes in comparison with that pertaining to nonalcoholic fatty liver disease-associated genes. The input list of platelet count-associated variants (P < 1 × 10^-6) was generated by searching the United Kingdom Biobank genome-wide association studies database as provided by Neale’s lab resource (http://www.nealelab.is/uk-biobank/). The input list associated with nonalcoholic fatty liver disease includes 928 genes/proteins obtained by data mining[5]. The analysis was performed by applying the functional enrichment and interaction network analysis (FunRich) tool[46].