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. 2021 Jan 28;27(4):305–320. doi: 10.3748/wjg.v27.i4.305

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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Functional assessment of variants associated with laboratory hematological-related traits. A-C: Functional analysis of genes significantly associated with platelet, leukocyte, and neutrophil count in the whole genome-wide association studies dataset (452264 individuals whose data are included in the United Kingdom Biobank). Functional enrichment analysis was performed using the FunRich tool, while Bonferroni and Benjamini-Hochberg methods were used to correct for multiple testing. D-E: Charts show fold changes in biological processes of genes associated with leukocyte or neutrophil counts vs biological processes of genes associated with platelet count. The input list of genes associated with platelet count, leukocyte count, and neutrophil count (P < 1 × 10^-8) was generated by searching the United Kingdom Biobank genome-wide association studies database.