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. 2020 Aug 19;28(1):382–400. doi: 10.1038/s41418-020-00607-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a The Venn diagram showed DEGs in breast cancer tissues and their paired adjacent tissues. DEGs in EPI sensitive group and non-sensitive group, along with 103 overlapped DEGs were also shown. Genes with P < 0.05 and |fold change| > 2 were considered as DEGs. b The volcano plot: green, red, and black points represented downregulated (n = 105), upregulated (n = 185), and no statistically significant difference genes, respectively, in the EPI non-sensitive group versus the EPI sensitive group. X-axes showed log₂ (fold change) and y-axes showed −log₁₀ (P value). c The heatmap and cluster analysis: EPI non-sensitive group: blue, EPI sensitive group: pink. Red denoted high expression and green represented low expression. The high expression of AQP1 in EPI sensitive group was shown. Not all DEGs in the figure were labeled. d OS (left panel) and PFS (right panel) curves of IDC patients treated with CEF-based therapies (upper panel) or non-CEF-based therapies (lower panel) with AQP1 expression (log-rank test). e OS (left panel) and PFS (right panel) curves of patients with high expression of AQP1 (upper panel) or low expression of AQP1 (lower panel) who received CEF-based therapies or non-CEF-based therapies (log-rank test). f OS (left panel) and PFS (right panel) curves of IDC patients treated with CMF-based therapies with AQP1 expression (log-rank test). g OS (left panel) and PFS (right panel) curves of patients with high expression of AQP1 (upper panel) or low expression of AQP1 (lower panel) who received CEF-based therapies or CMF-based therapies (log-rank test). h Representative immunohistochemical images of AQP1 expression in the EPI non-sensitive group (n = 37) and the EPI sensitive group (n = 33), respectively. Scale bars: 100 μm, (left panel). The AQP1 expression was higher in the EPI sensitive group than the EPI non-sensitive group (Mann–Whitney U test, P = 0.0378; right panel).