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. 2020 Jul 23;28(1):203–218. doi: 10.1038/s41418-020-0592-2

Fig. 5. Repeated IN delivery of MSC-CS significantly decreases brain amyloidosis.

Fig. 5

a 6E10 immunostaining comparing brain plaque load between MSC-CS- and PBS-treated mice (left panels). In the middle and right panels, higher magnification of plaques in cortex (c) and hippocampus (h) showing MSC-CS-mediated changes in terms of aggregate density, and absence of the central plaque core. b, c Plaque quantification in the cortex and the hippocampus. Quantitative data are expressed as scatter plots with mean ± SEM. *P < 0.05, Student’s t test.