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. 2020 Sep 4;35(1):142–148. doi: 10.1038/s41433-020-01173-7

Fig. 1. Multimodal imaging from the right eye of a diabetic patient with proliferative diabetic retinopathy.

Fig. 1

a Ultra-pseudocolor image demonstrated retinal hemorrhages, microaneurysms, cotton wool spots, hard exudates, and IRMA (intraretinal microvascular abnormalities). b, c In the ultra-widefield fluorescein angiography early-phase and late-phase images, numerous regions of hyperfluorescence with leakage may be seen corresponding to areas with microaneurysms and retinal neovascularization. Staining of pan-retinal laser photocoagulation scars are also evident. d The widefield en face OCTA image including the whole retina has vessels of different colors based on their depth. This image demonstrates regions of retinal ischemia (highlighted with blue arrowheads). e The OCTA image segmented at the vitreous level demonstrates the presence of a neovascularization at the level of the optic disc. Ultra-widefield pseudocolor and fluorescein angiography images were obtained with the California Optos device (Dunfermline, United Kingdom). The widefield OCTA images were performed with the Plex Elite 9000 device (Carl Zeiss Meditec Inc., Dublin, CA, USA).