Table 2.
Estimated per nucleotide per-generation mutation rates in mice from multiple studies using different estimation methods.
| Samples | Sequence data | Estimated μ (×10−9) | Estimation method | Reference |
|---|---|---|---|---|
| C3H/HeNj (JAN) | Whole-genome sequencing | 7.9 (CIs: 7.3‒8.5) | Site frequency spectrum | This study |
| C57BL/6J (CRL) | Whole-genome sequencing | 5.4 (CIs: 4.6‒6.5) | Expected coalescence time | Uchimura et al. (2015) |
| C57BL/6J (CRL) | Sanger sequencing | 6.8‒6.9 | One generation | Uchimura et al. (2015) |
| C57BL/6 (NR) | Whole-genome sequencing | 6.7‒7.0a | One-generation pedigree | Milholland et al. (2017) |
| CB57BL/6 × 129S5 (WSI) | Whole-genome sequencing | 3.9 (CIs: 3.7‒4.2) | One-generation pedigree | Lindsay et al. (2019) |
| CB57BL/6 × CBA/Ca (HSD) | Whole-genome sequencing | 3.8 (CIs: 3.0‒4.6) | One-generation pedigree | Adewoye et al. (2015) |
| Murids (UCSC) | Assembled genomes | 3.0‒3.2 | Phylogenetic | Eőry et al. (2010) |
| Mus | Various target sequences | 37 | Average over various studies | Lynch (2010) |
CIs 95% confidence intervals (when provided), CRL Charles River Labs, HSD Harlan Sprague Dawley Inc., JAN Janvier Labs, NR not reported, UCSC University of California, Santa Cruz, WSI Wellcome Trust Sanger Institute.
aMilholland et al. (2017) mutation rate estimation is based on an expected false-discovery rate of 0.25.