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. 2020 Sep 23;46(2):478–485. doi: 10.1038/s41386-020-00864-9

Fig. 3. Reproducibility and clinical relevance of the ketamine connectome (CFPs) and nodal fingerprints (NFPs).

Fig. 3

a The ketamine functional connectivity fingerprints identified in Cohort A were examined in Cohorts B and C. Ketamine significantly increased all connectivity fingerprints during infusion, except the nodal strength (nS) NFP in Cohort B. These findings demonstrate the robustness and reproducibility of the ketamine CFP. b In three cohorts of healthy participants, ketamine significantly increased connectivity of previously established antidepressant fingerprints. These findings demonstrate the clinical relevance of the ketamine CFP and its generalizability to antidepressants with differing initial neurochemical targets. c, d Across healthy and depressed subjects, there are high associations between the total connectivity of ketamine and antidepressant fingerprints. AA Akiki–Abdallah hierarchical connectivity atlas, AA-50 CFP using AA at 50 modules, AA-24 CFP using AA at 24 modules, FC full connectome using 424 nodes (i.e., A424), neNRS NFP using nodal external network-restricted strength, niNRS NFP using nodal internal NRS. * is used for p ≤ 0.05, ** for p ≤ 0.01, *** for p ≤ 0.001, **** for p ≤ 0.0001, ****** for p ≤ 0.000001. z is computed as the standardized sum of weighted estimates of connectivity per subject per fingerprint.